L-Taurine
Function-
L- Taurine is classified as an essential amino acid and therefore
must be required by the diet. Taurine has been considered non essential,
however, it plays a vital role in the development of preterm and
newborn infants. Taurine can be made from cysteine but may not be
able to convert a sufficient amount for human need. Taurine is found
in every cell and is most concentrated in the central nervous system,
heart, muscle, retina, and white blood cells. It is also found in
the kidney, liver, nasal membranes, adrenal glands, pituitary, thymus,
digestive tract and salivary glands.
Taurine
is the most abundant amino acid in the developing brain and the
second most abundant (glutamic acid is first) in the adult brain.
Taurine acts as an inhibitory neurotransmitter and is concentrated
in the hippocampus (memory center), olfactory bulb (taste and smell)
and the pineal gland (responsible for circadian rhythm).
Taurine
is the most abundant amino acid in heart tissue and surpasses the
concentration of all other amino acids combined. It also regulates
calcium metabolism in the heart tissue and modulates enzyme activity
related to heart muscle contraction.
Taurine
is found to be the most concentrated amino acid in the retina of
humans and of any other species studied. There has been no conclusion
for taurine deficient blindness in humans but in cats it has shown
to occur and is reversed when taurine is replaced. Taurine also
has protective characteristics for numerous functions of the eye.
Taurines
most important function is to stabilize nerve cell membranes for
proper communication throughout the body. It does this by balancing
the flow of sodium, calcium and other ions across the cell membrane.
If the cell membrane becomes electrically unstable the cells may
fire too rapidly and create the effects of seizures such as epilepsy.
Taurine,
methionine and glycine are the three most essential amino acids
for promoting gallbladder health. Taurine is necessary for the formation
of taurocholic acid found in bile which breaks down fat in the small
intestine. Men have a greater ability to make taurine than women
and it is a fact that women are at a much greater risk for gallbladder
dysfunction which leads to many unnecessary gallbladder surgeries
per year.
Diabetes
increases the body's requirements for taurine and conversely supplementation
with taurine and cystine may decrease the need for insulin.
Deficiency-
There is no disease condition solely related to the deficiency of
taurine, however, it easy to see the importance of this amino acid
and how it affects the overall health and wellness of the organism.
Taurine deficiency may be related to seizures, anxiety, impaired
brain function, eye conditions, arrhythmias, and gallbladder dysfunction.
Sources-
Taurine is found in eggs, fish, meat, and milk, but not in vegetable
proteins. It can be synthesized from cysteine in the liver and from
methionine elsewhere in the body, as long as sufficient quantities
of vitamin B6 are present.
Precautions-
Newborns have little or no ability to synthesize taurine and depend
upon the mother for this nutrient source. Babies fed cow’s milk
or formula will not get their requirements for immune development
unless supplied with breast milk. Newborns fed formula generally
have higher bilirubin levels that lead to jaundice. Jaundice may
be attributed from the stress of birth and the liver and/or gallbladder
may not be fully functional. Jaundice is rare with breast fed infants
or if there is taurine supplemented when needed.
Excessive
losses of taurine through the urine can be caused by intestinal
problems, an overgrowth of Candida, physical or emotional stress
and a zinc deficiency. Excessive alcohol consumption causes the
body to lose its ability to utilize taurine properly and is also
associated with high urinary losses of taurine.
Requirements-
There is no Recommended Dietary Allowances (RDA) listed. Individual
needs may differ due to clinical conditions, biochemical individuality
and absorption. All sources of nutrients should be consumed in their
most natural state, in the form of a variety of foods or supplements
when necessary. Free form amino acid supplements are immediately
absorbed by the body and should be consumed with natural occurring
cofactors for best results. Consulting with a physician that is
properly trained in the natural healing sciences and amino acid
therapy may be needed for optimum results.
Written
by Jerome Rerucha D.C.
References-
1.Corby, W. G., and Martin, W. G. The synthesis of taurine from
sulfate VIII. The effect of potassium (38580). Proc. Soc. Exper.
Biol. Med., 148:544-549, 1975.
2. Gordon, S. M., Does the alcoholic's remedy come in a pill? Behavior
Healthy Tomorrow 10(4) SR29-30, August 2001.
3. Hamosh, M., Breastfeeding: unraveling the mysteries of mother's
milk. Medscape Women's Health, 1 (9), 4, September 1996.
4. Hansen, S. H., The role of taurine in diabetes and the development
of diabetic complications. Diabetes Metab Res Review, 17(5), 330-46,
September-October 2001
5. Bankier, A., Turner, M., and Hopkins, I. J., Pyridoxine dependent
seizures—a wider clinical spectrum. Arch. Dis. Child., 58:415-418,
1983.
6. Barbeau, A., Inoue, N., Tsukada, Y., and Butterworth, R. F.,
The neuropharmacology of tau-rine. Life Sci., 1 7:669-678.
7. Baskin, S. I., Klekotka, S.)., Kendrick, Z. V., and Bartuska,
D. G., Correlation of platelet taurine levels with thyroid function.
/. Endocrinol. Invest, 2:245, 1979..
8. De Luca, A., and et al., Taurine and skeletal muscle ion channels.
Advanced Experience ical Biology, 483, 45-56, 2000.